Biotransformation

The structures of drug molecules are becoming increasingly complex as scientists seek to improve potency, selectivity and safety. As a result many new drugs contain one or more chiral centers and are marketed as a single enantiomer pharmaceutical.

Enzymatic reactions (Biotransformation) are often unique in their potential to produce fine chemicals in high optical purity. For example, cloned carbonyl reductases and alcohol dehydrogenases are used in a several instances to commercially produce fine chemicals in high optical purity.

When challenged with a chemical process requiring a biotransformation, Thesis Chemistry turns to the specialized technologies of Daicel Chemical Industries, Ltd. Daicel's technologies in biotransformation include proprietary cloned enzyme and microbial libraries and biomanufacturing capacity from 2 L to 55 m3 fermentors. Strict confidentiality is maintained and our partner executes a secrecy agreement with the customer before any chemistry is discussed. This relationship brings the best processing technologies to bear on your project without complicating your outsourcing and development decisions. In the end you win with a reduced outsourcing burden, an improved technical solution and a shortened time and cost of development.